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Back pain medications can be divided into several different categories. A few of the most popular ones to treat back pain or neck pain are opioids, muscle relaxants, and antidepressants. It depends on the type of pain you are experiencing as well as how your body responds to the drug. You might find that taking a stronger prescription medication like an opioid helps if your neck or back pain worsens. Opioids that block pain by interacting with receptors on nerve cells in the body and the brain include Tramadol 100mg tablet, oxycodone, and hydrocodone. This type of tramadol hydrochloride formulation comes in tablet form and is normally taken as directed every 4 to 6 hours. It is used to treat sciatica, back pain, and postoperative discomfort following spine surgery. Tramadol pills and other opioid painkillers should only be used as directed by a physician and should not be used longer than necessary.